HEMATOLOGY MCQ – Exercise 14

The multiple choice questions in this online test paper focuses on HEMATOLOGY MCQ. If you are looking for self evaluation of your PG Medical entrance exam preparation then this online HEMATOLOGY MCQ Test Paper will help you to evaluate your exam preparation.

Instruction for REPRODUCTIVE BIOLOGY/ REPRODUCTIVE MEDICINE / INFERTILITY MCQs:

1- This online MCQ practice test paper contains 30 questions.
2- Each question in this online practice test paper have four options and only 1 option is correct.
3- You can view the answers of this practice test paper after submitting the practice test paper.
Note: The answers mentioned at the end of practice test are the best suitable option as per our knowledge. Users shall cross-check the answers with their textbooks.

Q 1. earliest neurologic manifestation of cobalamin deficiency is

numbness and paresthesia in extremities

motor weakness

ataxia

sphincter disturbances

Q 2. folic acid supplementation to prevent neural tube defect should be started at

conception

first 4 weeks of pregnancy

first 8 weeks of pregnancy

first 12 weeks of pregnancy

Q 3. maternal folate metabolic abnormality identified in neural tube defect fetuses

mutations in methionine synthesis

mutations in serine-glycine hydroxymethylase

autoantibodies to folate receptors

reduced activity of 5,10 methylene-THF reductase

Q 4. dose of folic acid providing protective effect against neural tube defect at conception

.1 mg daily

.2 mg daily

.3 mg daily

.4 mg daily

Q 5. malabsorption of cobalamin occurs if terminal ileum is removed of length of approx

.2 meter

.5 meter

.8 meter

1.2 meter

Q 6. following pathological situation seen in cobalamin deficiency

demyelination

axonal degeneration

neuronal death

all of the above

Q 7. following enzyme deficiency causes homocystinuria

methionine reductase

MTHFR

cystathionine synthase

all of the above

Q 8. bone marrow finding in folate or B12 deficiency megaloblastic anemia include all except

hypercellularity

increased myeloid / erythroid ratio

nuclear-cytoplamic asynchrony in RBC precursors

fenestrated nuclear chromatin in RBC precursors

Q 9. incidence of pernicious anemia is increased in

graves disease

myxedema

thyroiditis

all of the above

Q 10. true regarding pernicious anemia

unusually common in agammaglobulinemia

H.pylori infection is infrequent

gastric atrophy spares the antrum

all of the above

Q 11. hematologic manifestation of cobalamin deficiency due to

anemia

leucopenia

thrombocytopenia

all of the above

Q 12. macrocytosis causes include all except

hemolysis

aplastic anemia

liver disease

hyperthyroidism

Q 13. following structure involvement is uncommon in cobalamin deficiency

peripheral nerves

spinal cord

cerebellum

cereberum

Q 14. neutrophils nucleus of ≥ 6 lobes suggestive of

megaloblastic anemia

CML

AML

multiple myeloma

Q 15. false statement regarding juvenile pernicious anemia

gastric atrophy

achlorhydria

serum IF antibodies present

parietal cell antibodies present

Q 16. folic acid supplementation reduces risk of stroke by

18%

25%

Q 17. false regarding pernicious anemia

rare under the age of 30 years

average age of presentation is 60 years

men more effected than women

caused by absence of IF

Q 18. true regarding pernicious anemia

hypergastrinemia

pentagastrin fast achlorhydria

relatives have increased incidence of disease

uncommon in patients with agammaglobulinemia

Q 19. true statement regarding megaloblastic anemia due to cobalamin deficiency

raised serum methylmalonic acid, elevated homocystiene

reduced serum methylmalonic acid, reduced homocystiene

raised serum methylmalonic acid, reduced homocystiene

reduced serum methylmalonic acid, elevated homocystiene

Q 20. cobalamindeficiency involves

blood

GIT

nervous system

all of the above

Q 21. prophylactic folic acid in pregnancy reduces subsequent incidence of

ALL

Hodgkin lymphoma

astrocytoma

hemangioma

Q 22. most frequently affected tissues in cobalamin and folate deficiencies

epithelial cell surfaces of mouth

bone marrow

peripheral smears

epithelial cell surfaces of the small intestine

Q 23. value of MCV diagnostic of megaloblastic anemia

>80 fL

>90 fL

>100 fL

>110 fL

Q 24. following enzyme deficiency have an increased risk of vascular disease

methionine synthase

MHTFR

cystathionine synthase

all of the above

Q 25. megaloblastoid morphologic picture of RBC series is seen in

hemolysis

pernicious anemia

myelodysplasia

all of the above

Q 26. mutation in cubulin receptor leading to selective defect in cobalamin absorption occurs in

Stickler syndrome

Imerslund-Grasbeck syndrome

Cogans syndrome

menkes syndrome

Q 27. evidence of ineffective erythropoiesis includes

reduced haptoglobins

positive urine hemosiderin

raised serum lactate dehydrogenase

all of the above

Q 28. true regarding pernicious anemia

gastric atrophy does not affect antrum of stomach

90% of patients have antiparietal cell antibody

~ 80% of patients have anti-IF antibody

all of the above

Q 29. true regarding pernicious anemia

gastric epithelium atypia common

hypergastrinemia common

gastric polyps common

all are true

Q 30. megaloblastic anemia is seen in all except

hereditary TC I deficiency

TC II deficiency

orotic aciduria

imerslund Grasbeck disease

HEMATOLOGY MCQ – Exercise 14

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HEMATOLOGY MCQ – Exercise 14

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