HEMATOLOGY MCQ – Exercise 18

The multiple choice questions in this online test paper focuses on HEMATOLOGY MCQ. If you are looking for self evaluation of your PG Medical entrance exam preparation then this online HEMATOLOGY MCQ Test Paper will help you to evaluate your exam preparation.

Instruction for REPRODUCTIVE BIOLOGY/ REPRODUCTIVE MEDICINE / INFERTILITY MCQs:

1- This online MCQ practice test paper contains 30 questions.
2- Each question in this online practice test paper have four options and only 1 option is correct.
3- You can view the answers of this practice test paper after submitting the practice test paper.
Note: The answers mentioned at the end of practice test are the best suitable option as per our knowledge. Users shall cross-check the answers with their textbooks.

Q 1. in aplastic anemia peripheral blood smear shows all except

decreased MCV

few or absent reticulocytes

normal lymphocyte number

reduced platelets and granulocytes

Q 2. pathognomic cell in bone marrow of PRCA patients with B19 parvovirus infection is

uninuclear megakaryocyte

giant megakaryoblast

giant pronormoblast

ringed sideroblast

Q 3. dyskeratosis congenital is due to mutations in

DKC1

TERC

TERT

any of the above

Q 4. severe aplastic anemia is defined by

absolute neutrophil count < 500/ µL

platelet count <20,000/ µL

absolute reticulocytes count <60,000/ µL

all of the above

Q 5. addition of which of the following to ALG or ATG increases response rates in aplastic anemia

azithromycin

zinc

cyclosporine

vitamin E

Q 6. regarding Fanconi’s anemia all are true except

autosomal dominant disorder

short stature, café au lait spots

Type A is due to mutation in FANCA

increased risk of malignancy

Q 7. true statement regarding aplastic anemia include

aplastic anemia is a disease of the young

agranulocytosis is more frequent in elderly and women

in single lineage failure syndromes progression to pancytopenia or leukemia is unusual

all of the above

Q 8. following is a feature of MDS

cytopenias

dysmorphic cellular bone marrow

ineffective blood cell production

all of the above

Q 9. not a feature of bone marrow cytology in aplastic anemia

dilute aspirate

hematopoietic cells occupying <50% of marrow

megakaryocytes greatly reduced or absent

mild megaloblastic erythropoiesis

Q 10. PRCA patients with persistent B19 parvovirus infection respond best to

glucocorticoids

IV Ig therapy

cyclosporine

daclizumab

Q 11. chronic cyclosporine side effects of cyclosporine treatment includes all except

nephrotoxicity

hepatotoxicity

hypertension

seizures

Q 12. single best method of preventing the spread of infection while treating patients of aplastic anemia is

prompt institution of parenteral broad spectrum antibiotic

hand washing

non absorbed antibiotics for gut decontamination

total reverse isolation

Q 13. Shwachman-Diamond syndrome include all except

pancreatic insufficiency

malabsorption

eosinophilia

risk of aplastic anemia

Q 14. aplastic anemia is associated with

fanconi’s anemia

PNH

dyskeratosis congenita

all of the above

Q 15. initial oral dose of cyclosporine in treatment of aplastic anemia in adults is

2 mg/kg per day

8 mg/kg per day

12 mg/kg per day

20 mg/kg per day

Q 16. horse ATG dose in treatment of aplastic anemia is

40 mg /kg per day for 1 day

40 mg /kg per day for 2 days

40 mg /kg per day for 3 days

40 mg /kg per day for 4 days

Q 17. unusual in aplastic anemia

infection on presentation

lymphadenopathy

splenomegaly

all of the above

Q 18. PRCA may be associated with

thymoma

large granular lymphocytosis

hypogammaglobulinemia

all of the above

Q 19. trough blood levels of cyclosporine in treatment of aplastic anemia should be between

150 and 200 ng / mL

250 to 400 ng / mL

450 to 600 ng / mL

650 to 800 ng / mL

Q 20. congenital PRCA is which variety of PRCA

fetal red blood cell aplasia

hereditary pure red cell aplasia

acquired pure red cell aplasia

idiopathic

Q 21. cells in the bone marrow helpful in differentiatin aplastic anemia from hypoplastic myelodyspalstic syndromes

CD34 positive stem cells

CD38 positive stem cells

CD42 positive stem cells

CD46 positive stem cells

Q 22. drug that may cause PRCA

phenytoin

azathioprine

erythropoietin

all of the above

Q 23. most common early symptom in aplastic anemia

bleeding

infection

weight loss

jaundice

Q 24. improvement in granulocyte number in aplastic anemia with standard regimen of ATG + cyclosporine generally apparent within

1 month of treatment

2 months of treatment

3 months of treatment

4 months of treatment

Q 25. in aplastic anemia responders MDS develops in

10%

15%

20%

25%

Q 26. following have no value in treating severe acquired aplastic anemia

hematopoietic growth factors

glucocorticoids

ATG (anti thymocyte globulin)

bone marrow transplantation

Q 27. dyskeratosis congenita characterized by triad which include all excpt

reticular hyperpigmentation

pancreatic insufficiency

nail dystrophy

mucosal leucoplakia

Q 28. congenital PRCA is also known as

Fanconi anemia

Scwachman-Diamond syndrome

kostmann’s syndrome

Diamond-Blackfan syndrome

Q 29. in chronic anemia iron chelators are given at around after how many blood transfusions

Q 30. PRCA is characterized by

anemia

reticulocytopenia

absent or rare erythroid precursor cells in bone marrow

all of the above

HEMATOLOGY MCQ – Exercise 18

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HEMATOLOGY MCQ – Exercise 18

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