HEMATOLOGY MCQ – Exercise 23

The multiple choice questions in this online test paper focuses on HEMATOLOGY MCQ. If you are looking for self evaluation of your PG Medical entrance exam preparation then this online HEMATOLOGY MCQ Test Paper will help you to evaluate your exam preparation.

Instruction for REPRODUCTIVE BIOLOGY/ REPRODUCTIVE MEDICINE / INFERTILITY MCQs:

1- This online MCQ practice test paper contains 30 questions.
2- Each question in this online practice test paper have four options and only 1 option is correct.
3- You can view the answers of this practice test paper after submitting the practice test paper.
Note: The answers mentioned at the end of practice test are the best suitable option as per our knowledge. Users shall cross-check the answers with their textbooks.

Q 1. osteoclasts activating factors from myeloma cells are mediated by

IL-1

RANK ligand

TNF

all of the above

Q 2. growth, drug resistance and migration in multiple myeloma is mediated by

Ras/Raf/mitogen activated protein kinase,PI3-K/Akt, protein kinase C signaling cascades respectively

PI3-K/Akt, protein kinase C signaling cascades, Ras/Raf/mitogen activated protein kinase respectively

Ras/Raf/mitogen activated protein kinase, protein kinase C signaling cascades, PI3-K/Akt respectively

PI3-K/Akt, Ras/Raf/mitogen activated protein kinase, protein kinase C signaling cascades respectively

Q 3. antigenic determinants formed by the unique structure of the antigen binding portion of the molecule are called

isotypes

allotypes

idiotypes

none of the above

Q 4. most common translocation in multiple myeloma

t (10; 14)

t (11; 14)

t (12; 14)

t (13; 14)

Q 5. feature of multiple myeloma cells include all except

round or oval shape

eccentric nucleus with coarsely clumped chromatin

densely eosinophilic cytoplasm

perinuclear clear zone containing golgi apparatus

Q 6. plasma cells are produced in

lymph glands

spleen

thymus

all of the above

Q 7. in multiple myeloma most common infection is

osteomyelitis

otitis

cholecystitis

pyelonephritis

Q 8. antibody molecule is composed of

2 heavy chains and 2 light chains

2 heavy chains and 1 light chains

1 heavy chains and 2 light chains

any of the above

Q 9. M component detected in serum electrophoresis in

plasma cell disorders

chronic lymphocytic leukemia

chronic myeloid leukemia

all of the above

Q 10. according international staging system foe multiple myeloma, in stage III β2 microglobulin levels are more than

2.5 mg/dL

3.5 mg/dL

4.5 mg/dL

5.5 mg/dL

Q 11. quantity of light chains excreted daily by kidneys normally is

<10 mg

<20 mg

<30 mg

<40 mg

Q 12. church spire sharp peak on serum electrophoresis detected in

normal individuals

polyclonal immunoglobulinopathy

monoclonal gammopathy

none of the above

Q 13. following interleukins play role in myeloma cell proliferation

Q 14. light and heavy chains in antibody are linked by which bond

phosphate

disulphide

sulphur

all of the above

Q 15. M component detected in serum electrophoresis in

rheumatoid arthritis

myasthenia gravis

lichen myxedematosus

all of the above

Q 16. regarding multiple myeloma true statements include

rare under the age of 40 years

median age at diagnosis is 70 years

more common in males than females

all of the above

Q 17. regarding bone pain in myeloma include all except

affects ~70% of patients

located to back and ribs

precipitated by movement

worse at night

Q 18. what percentage of plasma proteins constituted by immunoglobulins

Q 19. immunoglobulins form a broad peak in which region

alpha region

beta region

gamma region

delta region

Q 20. antibody must be present in serum at which concentration to be detectable by serum electrophoresis

.3g/dL

.4g/dL

.5g/dL

.6g/dL

Q 21. following interleukins is called B cell stimulating factors or B cell growth factors

all of the above

Q 22. DKK1 (Dickhoff-1 ) produced by myeloma cells causes

osteoblastic activation

osteoblastic suppression

osteoclastic suppression

osteoblastic activation

Q 23. M component is composed of

intact antibody molecule of any heavy chain subclass

altered antibody

antibody fragment

any of the above

Q 24. most common pathogen in lungs in multiple myeloma is

pseudomonas aeruginosa

kliebsella pneumoniae

hemophilus influnzae

legionella pneumophilia

Q 25. most common form of myeloma

IgG

IgA

IgD

none of the above

Q 26. localized lesion in multiple myeloma may be palpated on

skull

clavicles

sternum

all of the above

Q 27. M in M component indicates

myeloma

monocomponent

monclonal

miscellaneous

Q 28. M component detected in serum electrophoresis in

cirrhosis

sarcoidosis

Gaucher disease

all of the above

Q 29. regarding bony lesion in myeloma include all except

due to bony destruction by osteoclasts

suppression of osteoblastic new bone formation

serum alkaline phosphatase is usually normal

all of the above

Q 30. Bence Jones proteins in urine of multiple myeloma patient represents

light chains

heavy chains

altered antibody

any of the above

HEMATOLOGY MCQ – Exercise 23

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HEMATOLOGY MCQ – Exercise 23

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