HEMATOLOGY MCQ – Exercise 29

The multiple choice questions in this online test paper focuses on HEMATOLOGY MCQ. If you are looking for self evaluation of your PG Medical entrance exam preparation then this online HEMATOLOGY MCQ Test Paper will help you to evaluate your exam preparation.

Instruction for REPRODUCTIVE BIOLOGY/ REPRODUCTIVE MEDICINE / INFERTILITY MCQs:

1- This online MCQ practice test paper contains 30 questions.
2- Each question in this online practice test paper have four options and only 1 option is correct.
3- You can view the answers of this practice test paper after submitting the practice test paper.
Note: The answers mentioned at the end of practice test are the best suitable option as per our knowledge. Users shall cross-check the answers with their textbooks.

Q 1. True regarding ADAMTS 13

ADAMTS refers to ‘A Disintegrin like and metalloprotease with thromboSpondin type 1 motif’

human ADAMTS 13 gene is located on chromosome 9q34

ADAMTS 13 molecule depends upon zinc and calcium ions for activity

all of the above

Q 2. true statement regarding Weibel-Palade bodies

are organelles in the vascular endothelium

major constituents of Weibel-Palade bodies are non vWF and P selectin

George Emil Palade won the Nobel Prize in 1974

all of the above

Q 3. immunomodulatory therapies useful in refractory or relapsing TTP includes

rituximab

vincristine

cyclophosphamide

all of the above

Q 4. true regarding TTP

TTP is more common in HIV patients and pregnant women

coagulation studies are essentially normal in TTP

severe bleeds are usually absent

all of the above

Q 5. Upshaw-Schulman syndrome is best related to

idiopathic TTP

inherited TTP

medication related TTP

TTP in pregnant women

Q 6. true statement regarding Weibel-Palade bodies

Weibel-Palade bodies play a dual role in blood coagulation hemostasis and inflammation

Weibel-Palade bodies are the main source of vWF

Weibel-Palade bodies are secretory organelles used for post synthesis storage in endothelial cells

all of the above

Q 7. in TTP, hyaline thrombi without inflammatory changes in vessel wall may be found in

arterioles

capillaries

venules

all of the above

Q 8. True regarding ADAMTS 13

ADAMTS 13 prevents inappropriate microvascular platelet aggregation

deficiency of ADAMTS 13 is a finding for TTP

vWF multimers is the physiologic substrate for ADAMTS 13

all of the above

Q 9. following vWD type is most severe

type I

type IIA

type IIB

type III

Q 10. most common inherited bleeding disorder is

Glanzmann’s thrombasthenia

Bernard Soulier syndrome

von wilebrand disease

hemophilia

Q 11. all are used in the treatment of TTP except

platelet concentrates

plasma exchange

FFP

solvent/detergent treated plasma ( SD-FFP)

Q 12. severity of TTP is estimated by the degree of

anemia

thrombocytopenia

serum LDH level

all of the above

Q 13. findings in TTP includes

abdominal pain, nausea, vomiting and weakness

seizures and fluctuating focal deficits

thrombocytopenia without leukopenia

all of the above

Q 14. feature of TTP include all except

microangiopathic hemolytic anemia

renal failure

hepatic failure

neurologic dysfunction

Q 15. idiopathic TTP is more common in

women

HIV infection

pregnant women

all of the above

Q 16. Upshaw-Schulman syndrome is related to

multiple transfusions

TTP

Uremia

CHF

Q 17. prevention of bleeding in patients in inherited disorders of platelet dysfunction include

Prestorage leukodepleted platelets transfusion

desmopressin

EACA or tranexamic acid

all of the above

Q 18. acquired platelet dysfunction due to uremia responds to

dialysis

DDAVP

conjugated estrogens

all of the above

Q 19. following supports the diagnosis of TTP

increased LDH

increased indirect bilirubin

decreased haptoglobin

all of the above

Q 20. following vWD is not inherited as autosomal dominant trait

type I

type IIA

type IIB

type III

Q 21. not a feature of TTP

severe coombs positive hemolytic anemia

near normal prothrombin time

near normal fibrinogen level

near normal FDP level

Q 22. absence of the platelet GpIIbIIIa receptor seen in

Glanzmann’s thrombasthenia

Bernard Soulier syndrome

Hermansky-Pudlak syndrome

Heyde’s syndrome

Q 23. HUS features include all except

CRF

microangipathic hemolytic anemia

thrombocytopenia

frequently preceded by an episode of diarrhoea

Q 24. following is not a functional platelet disorder of adhesion

vWD

glanzmann’s thrombasthenia

Bernard-Soulier syndrome

uremia

Q 25. TTP is due to deficiency in the activity of

ADAMTS 11

ADAMTS 12

ADAMTS 13

ADAMTS 14

Q 26. HUS is a disease of

infancy and early childhood

adolescence

adults

elderly

Q 27. acquired platelet dysfunction can occur in

uremia

high dose penicillins

with cardiopulmonary bypass

all of the above

Q 28. normal plasma vWF level is

4 mg/L

6 mg/L

8 mg/L

10 mg/L

Q 29. thrombocytosis is due to deficiency of

Vitamin B12

Folic acid

Iron

Calcium

Q 30. following antiplatelet agent has been implicated in the causation of TTP

aspirin

ticlopidine

carvadilol

all of the above

HEMATOLOGY MCQ – Exercise 29

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HEMATOLOGY MCQ – Exercise 29

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