HEMATOLOGY MCQ – Exercise 35

The multiple choice questions in this online test paper focuses on HEMATOLOGY MCQ. If you are looking for self evaluation of your PG Medical entrance exam preparation then this online HEMATOLOGY MCQ Test Paper will help you to evaluate your exam preparation.

Instruction for REPRODUCTIVE BIOLOGY/ REPRODUCTIVE MEDICINE / INFERTILITY MCQs:

1- This online MCQ practice test paper contains 30 questions.
2- Each question in this online practice test paper have four options and only 1 option is correct.
3- You can view the answers of this practice test paper after submitting the practice test paper.
Note: The answers mentioned at the end of practice test are the best suitable option as per our knowledge. Users shall cross-check the answers with their textbooks.

Q 1. vitamin K dependent clotting factors possess which amino acid residues at their N termini

leucine

isoleucine

glutamic acid

tryptophan

Q 2. Fondaparinaux has a molecular weight of

1728

2728

3728

4728

Q 3. LMWH have an anti factor Xa: antithrombin activity ratio of

.2:1

.5:1

1:1

2:1

Q 4. true regarding fondaparinaux

bioavailability of s/c fondaparinux is 100%

plasma half life of fondaparinaux is 17 hours

fondaparinaux does not cause HIT

all of the above

Q 5. Direct Thrombin Inhibitors cleared by liver

melagatron

argatroban

ximelogatron

recombinant hirudins

Q 6. regarding LMWH true statement includes

major complication of LMWH is bleeding

protamine sulphate completely reverses anti factor IIa activity of LMWH

patients with high risk of bleeding are more safely treated with continuous iv UFH than s/c LMWH

all of the above

Q 7. range of therapeutic anti factor Xa levels with LMWH is

.5-1.2 units/mL

1.5-2.2 units/mL

2.5-3.2 units/mL

3.5-4.2 units/mL

Q 8. following drug used for thrombophylaxis has longest duration of action

fondaparinux

idraparinux

ximelagatron

argatroban

Q 9. true statement regarding Direct Thrombin Inhibitors include

activity of Direct Thrombin Inhibitors is independent of antithrombin

Direct Thrombin Inhibitors can bind to and inhibit the activity of soluble thrombin and also thrombin bound to fibrin

Direct Thrombin Inhibitors also have an antiplatelet effect

all of the above

Q 10. half life of warfarin in plasma is

~12 hours

~24 hours

~36 hours

~48 hours

Q 11. coagulation monitoring with LMWH is done by

aPTT

anti factor Xa levels

any of the above

Q 12. most specific diagnostic test for diagnosis of HIT

ELISA for antibodies against heparin-PF4 complexes

platelet activation assays

serotonin release assay

none of the above

Q 13. false statement regarding LMWH

can not be administered iv

prepared from unfractionated heparin

cleared by kidneys

resistance to LMWH is rare

Q 14. in atrial fibrillation, the risk of bleeding increases at what level of INR

>3.0

>3.5

>4.0

>4.5

Q 15. warfarin is a racemic mixture of

C and D isomers

M and N isomers

R and S isomers

X and Y isomers

Q 16. antithrombotic effect of warfarin depends upon reduction in the functional level of

factor VIII

factor IX

factor X

factor XI

Q 17. warfarin acts by inhibiting

vitamin K epoxide reductase

vitamin K reductase

vitamin K carboxylase

vitamin K hydrolase

Q 18. vitamin K dependent coagulation protein includes

factor VII

factor X

prothrombin

all of the above

Q 19. indications for LMWH monitoring include

renal insufficiency

obesity

pregnancy

all of the above

Q 20. INR in patients with prosthetic mechanical heart valves should be

1.5 to 2.0

2.0 to3.0

2.5 to 3.5

3.5 to 4.0

Q 21. natural anticoagulant includes

tissue factor pathway inhibitor

protein C and S

antithrombin

all of the above

Q 22. in atrial fibrillation, the risk of cardioembolic stroke increases at what level of INR

<1.7

<1.9

<2.1

<2.3

Q 23. plasma half life of LMWH is

4 hour

6 hour

8 hour

12 hour

Q 24. drugs useful in HIT

lepuridin

bivalirudin

fondaparinux

all of the above

Q 25. in unstable angina dose of LMWH is

30-50 units/kg

50-80 units/kg

80-100 units/kg

100-120 units/kg

Q 26. peak anti-factor Xa levels required when LMWH is given in prophylactic doses is

.1-.3 units/mL

.2-.5 units/mL

.5-.8 units/mL

.8-1.0 units/mL

Q 27. warfarin was initially developed as

diuretic

antibiotic

sedative

rodenticide

Q 28. LMWH have a mean molecular mass of

~5 saccharide units

~17 saccharide units

~30 saccharide units

~45 saccharide units

Q 29. aPTT is used to monitor the anticoagulant effect of all except

heparin

lepuridin

LMWH

Argatroban

Q 30. following best relates to HIT

antibodies of the IgM type

antibodies against neoantigens on PF4

more common in medical than surgical patients

more frequent in males than in females

HEMATOLOGY MCQ – Exercise 35

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HEMATOLOGY MCQ – Exercise 35

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