NEUROLOGY MCQ – Exercise 28

The multiple choice questions in this online test paper focuses on NEUROLOGY MCQ. If you are looking for self evaluation of your PG Medical entrance exam preparation then this online NEUROLOGY MCQ Test Paper will help you to evaluate your exam preparation.

Instruction for REPRODUCTIVE BIOLOGY/ REPRODUCTIVE MEDICINE / INFERTILITY MCQs:

1- This online MCQ practice test paper contains 30 questions.
2- Each question in this online practice test paper have four options and only 1 option is correct.
3- You can view the answers of this practice test paper after submitting the practice test paper.
Note: The answers mentioned at the end of practice test are the best suitable option as per our knowledge. Users shall cross-check the answers with their textbooks.

Q 1. true regarding PD

increased firing of neurons in STN

increased firing of neurons in GPi

excessive inhibition of thalamus

all of the above

Q 2. glutamate is the neurotransmitter for which pathways

globus pallidus externa-subthalamic nucleus

substantia nigra compacta-striatum

subthalamic nucleus- substantia nigra reticulata

globus pallidus interna-thalamic nucleus

Q 3. levodopa can be combined with

carbidopa

benserazide

entacapone

all of the above

Q 4. cause of neuropsychiatric symptoms in PD includes

accompanying Alzheimer`s disease

accompanying cortical dementia with lewy bodies

side effect of pharmacotherapy

all of the above

Q 5. parkinsonian symptoms develop when striatal dopamine depletion reaches

10-30% of normal

30-50% of normal

50-70% of normal

70-90% of normal

Q 6. symptoms that precedes onset of PD

rapid eye movement-behavioral disorder

micrographia

hypophonia

all of the above

Q 7. false regarding levodopa

it is precursor of dopamine

it is not metabolized centrally by dopa-decarboxylase

it is metabolized peripherally by dopa-decarboxylase

it is metabolized by COMT and MAO

Q 8. excitatory pathway includes

globus pallidus externa-subthalamic nucleus

striatum- globus pallidus interna

globus pallidus interna-thalamus

subthalamic nucleus- globus pallidus interna

Q 9. in PD classic gait is

festinating gait

pigeon gait

scissor gait

antalgic gait

Q 10. true regarding rest tremor in PD include all except

frequency of 4 to 6 Hz

appears bilaterally, first distally

may appear in lips, tongue and jaw

spares head and neck

Q 11. inhibitory pathway includes

globus pallidus externa-subthalamic nucleus

striatum- globus pallidus interna

globus pallidus interna-thalamus

all of the above

Q 12. which drug has neuroprotective function in PD

Levodopa

bromocriptine

selegiline

amantadine

Q 13. areas of brain not protected by blood brain barrier

posterior pituitary gland

pineal gland

pineal gland medial eminence of hypothalamus

all of the above

Q 14. postural instability in PD is tested by

swing test

push test

pull test

lift test

Q 15. early urinary incontinence, orthostatic hypotension, and dysarthria favors

Parkinson’s disease

Wilson disease

DLB

multiple system atrophy

Q 16. which statement suggests diagnosis other than PD

dystonia involving distal arm or leg

significant postural instability and falls in first year of illness

proximal and ipsilateral tremors

freezing of gait

Q 17. which drug has neuroprotective function in PD

selegilline

pramipexole

ropinirole

all of the above

Q 18. essential tremor features include all except

bilaterally

higher frequency (8 to 10 Hz)

postural dependency

aggravation with alcohol

Q 19. which antiparkinsonian drug is associated with valvular disease

levodopa

pergolide

pramipexole

rotigotine

Q 20. true statement includes

levodopa is a dopamine precursor

dopamine does not cross blood brain barrier

domperidome is a peripheral dopamine blocking agent

all of the above

Q 21. symptom which respond poorly to therapy in PD

bradykinesia

abnormal posture

balance difficulties

rigidity

Q 22. true regarding dyskinesias in PD

choreiform and dystonic movements

occurs as a peak dose effect

occurs at the beginning or end of the dose

all of the above

Q 23. predictors of dementia in PD include all except

early age of onset

akinetic rigid phenotype

presence of severe depression

persistent hallucinations

Q 24. true regarding familial Parkinson`s disease include

mutations in α-synuclein and ubiquitin carboxy terminal hydroxylase L1

characteristic histopathologic feature is lewy body

lewy body is eosinophilic cytoplasmic inclusion that contains neurofilaments and α-synuclein

all of the above

Q 25. which of the following manifests long before the onset of motor signs in PD

anosmia

depression

sleep disorders

all of the above

Q 26. early appearance of hallucinations favors

Parkinson’s disease

Wilson disease

DLB

Alzheimer’s disease

Q 27. most disabling motor feature of PD is

rest tremor

rigidity

bradykinesia

stooped posture

Q 28. GABA is the neurotransmitter for which pathways

globus pallidus externa-subthalamic nucleus

striatum- globus pallidus interna

globus pallidus interna-thalamus

all of the above

Q 29. symptom which respond poorly to therapy in PD

cognitive symptoms

abnormal posture

tremor

rigidity

Q 30. dopamine agonists readily cross blood brain barrier and act directly on postsynaptic dopamine receptors primarily of

D1 type

D2 type

D3 type

D4 type

NEUROLOGY MCQ – Exercise 28

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