NEUROLOGY MCQ – Exercise 60

The multiple choice questions in this online test paper focuses on NEUROLOGY MCQ. If you are looking for self evaluation of your PG Medical entrance exam preparation then this online NEUROLOGY MCQ Test Paper will help you to evaluate your exam preparation.

Instruction for REPRODUCTIVE BIOLOGY/ REPRODUCTIVE MEDICINE / INFERTILITY MCQs:

1- This online MCQ practice test paper contains 30 questions.
2- Each question in this online practice test paper have four options and only 1 option is correct.
3- You can view the answers of this practice test paper after submitting the practice test paper.
Note: The answers mentioned at the end of practice test are the best suitable option as per our knowledge. Users shall cross-check the answers with their textbooks.

Q 1. myoglobinuria in carnitine palmitoyltransferase II deficiency is precipitated by

prolonged exercise

fasting

infections

all of the above

Q 2. acyl-CoA must be linked to which of the following for transport into mitochondria

acyl-CoA dehydrogenase

cystinosin

carnitine

carnitine palmitoyltransferase I

Q 3. progressive external ophthalmoplegia includes all except

due to mtDNA mutations

inherited in a Mendelian fashion

onset is usually after puberty

ragged red fibers seen in muscle biopsy

Q 4. carnitine palmitoyltransferase II is present on

outer side of outer mitochondrial membrane

inner side of outer mitochondrial membrane

outer side of inner mitochondrial membrane

inner side of inner mitochondrial membrane

Q 5. MELAS include all except

cerebral lesions conform to a vascular distribution

partial motor or generalized seizures

serum lactic acid is elevated

muscle biopsies show ragged red fibres

Q 6. seizure disorder with mental retardation is a feature of

myophosphorylase deficiency

phosphofructokinase deficiency

phosphoglycerate kinase deficiency

beta enolase deficiency

Q 7. most common alpha glucosidase or acid maltase deficiency form

infantile form

childhood form

adult form

none of the above

Q 8. x linked recessive disorder includes

myophosphorylase deficiency

phosphofructokinase deficiency

phosphoglycerate mutase deficiency

phosphoglycerate kinase deficiency

Q 9. ragged red fibers is muscle cell with significant numbers of abnormal

mitochondria

golgi apparatus

cell membrane

nucleus

Q 10. following point mutation is most common in MELAS

A3243G point mutation in tRNALeu(UUR)

3252G point mutation in tRNALeu(UUR)

3256T point mutation in tRNALeu(UUR)

3271C point mutation in tRNALeu(UUR)

Q 11. chromosome is affected in autosomal dominant form of CPEO

4q35

10q24

15q22-26

all of the above

Q 12. MELAS include all except

focal lesions in frontal lobes

basal ganglia calcification

vascular territories are not respected

cerebral angiography essentially normal

Q 13. disorder of glycolysis causing exercise intolerance

myophosphorylase deficiency

phosphofructokinase deficiency

lactate dehydrogenase deficiency

all of the above

Q 14. Pompe`s disease includes

autosomal recessive disorder

caused by mutation of alpha glucosidase gene

enzyme replacement treatment beneficial in infantile onset type

all of the above

Q 15. to enter mitochondria fatty acid must first be converted to

Enoyl-acyl carrier

acyl-NADH

Acyl-CoA

amino acyl tRNA

Q 16. mitochondrial myopathy includes

CPEO (chronic progressive external ophthalmoplegia)

skeletal muscle-CNS syndromes

pure myopathy

all of the above

Q 17. calcium channelopathy includes

hypokalemic periodic paralysis

hyperkalemic periodic paralysis

paramyotonia congenita

Andersen-Tawil syndrome

Q 18. characteristic feature of myoclonic epilepsy with ragged red fibers is (MERRF) is

myoclonic epilepsy

cerebellar ataxia

progressive muscle weakness

all of the above

Q 19. twinkle is the gene product of

4q35

10q24

15q22-26

all of the above

Q 20. which is caused by maternally inherited point mutations of mitochondrial tRNA gene

Kearns –Sayre syndrome

MELAS

pompe`s disease

mitochondrial DNA depletion syndrome

Q 21. Kearns Sayre syndrome includes all except

spontaneous deletion occur in spermatozoa

sporadic disorder

caused by single mtDNA deletions

spontaneous deletion occur in ovum or zygote

Q 22. potassium channelopathy includes

hypokalemic periodic paralysis

hyperkalemic periodic paralysis

paramyotonia congenita

Andersen-Tawil syndrome

Q 23. maternally inherited point mutations of mitochondrial tRNA gene

Kearns-Sayre syndrome

MERRF

pompe`s disease

all of the above

Q 24. enzyme important in mtDNA replication is

carnitine palmitoyltransferase I

acid maltase

myoadenylate deaminase

POLG

Q 25. regarding lipid as a source of energy which is true

fatty acids are derived from circulating VLDL in blood

fatty acids are derived from triglycerides in muscle fibers

oxidation of fatty acids occur in mitochondria

all of the above

Q 26. carnitine palmitoyltransferase I is present on

outer side of outer mitochondrial membrane

inner side of outer mitochondrial membrane

outer side of inner mitochondrial membrane

inner side of inner mitochondrial membrane

Q 27. cardinal signs of mitochondrial disorders

diabetes mellitus

Addison`s disease

hypoparathyroidism

hyperaldosteronism

Q 28. Kearns Sayre syndrome includes all except

onset before 20 years of age

CPEO

diplopia

pigmentary retinopathy

Q 29. McArdle`s diseaseis also called

myophosphorylase deficiency

phosphofructokinase deficiency

lactate dehydrogenase deficiency

beta enolase deficiency

Q 30. human mitochondrial DNA includes

double stranded circular molecule

codes for transfer and ribosomal RNAs and polypeptides

directly inherited from cytoplasm of oocyte mainly

all of the above

NEUROLOGY MCQ – Exercise 60

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NEUROLOGY MCQ – Exercise 60

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