ENDOCRINOLOGY MCQs – Exercise 13

The multiple choice questions in this online test paper focuses on ENDOCRINOLOGY MCQ. If you are looking for self evaluation of your PG Medical entrance exam preparation then this online ENDOCRINOLOGY MCQ Test Paper will help you to evaluate your exam preparation.

Instruction for REPRODUCTIVE BIOLOGY/ REPRODUCTIVE MEDICINE / INFERTILITY MCQs:

1- This online MCQ practice test paper contains 30 questions.
2- Each question in this online practice test paper have four options and only 1 option is correct.
3- You can view the answers of this practice test paper after submitting the practice test paper.
Note: The answers mentioned at the end of practice test are the best suitable option as per our knowledge. Users shall cross-check the answers with their textbooks.

Q 1. ACTH stimulation leads to upregulation of Protein Kinase A (PKA) signaling pathway which leads to

increase in import of cholesterol esters

breaks cholesterol esters to cholesterol

increases availability and phosphorylation of CREB

all of the above

Q 2. cyclopentenoperhydrophenanthrane nucleus is a constituent of

steroids

insulin

pepsin

growth hormones

Q 3. 11 β-HSD1 is primarily expressed in

liver

lung

kidney

all of the above

Q 4. following enzymes converts 17 hydroxy progesterone to 11-deoxycortisol

17 α hydroxylase / 17, 20 lyase (CYP17 A1 )

21 hydroxylase (CYP21 A2)

11β- hydroxylase (CYP1 1B1)

3β-HSD2

Q 5. beyond what concentration cortisol bounds to albumin

5 µg/dl

15 µg/dl

25 µg/dl

45 µg/dl

Q 6. normally how much circulating cortisol is free form

<5%

<20%

<30%

<40%

Q 7. C19 steroids have predominantly which properties

androgenic

glucocorticoid

mineralocorticoid

all of the above

Q 8. action of mineralocorticoid include all except

immune response

blood pressure

vascular volume

electrolytes

Q 9. cortisol circulates in plasma as

free cortisol

protein bound cortisol

cortisol metabolites

all of the above

Q 10. which of the following enzyme converts pregnenolone to progesterone

17 α hydroxylase / 17, 20 lyase (CYP17 A1 )

21 hydroxylase (CYP21 A2)

11β- hydroxylase (CYP1 1B1)

3β-HSD2

Q 11. basic substrate for steroidogenesis is

triglycerides

cholesterol

amino acids

polysaccharides

Q 12. average daily secretion of aldosterone ranges between

5 to10 µg

10 to 15 µg

50 to 250 µg

300 to 600 µg

Q 13. basic structure of steroids is built upon

3 ring nucleus

4 ring nucleus

5 ring nucleus

6 ring nucleus

Q 14. transcortin binding property for cortisol includes

high affinity, low capacity

low affinity, high capacity

high affinity , high capacity

low affinity , low capacity

Q 15. function of 11 β-HSD1 is

converting inactive cortisone to active cortisol

converting cortisol to inactive cortisone

promote binding of free cortisol to transcortin

inhibit binding of free cortisol to transcortin

Q 16. following enzymes converts 17 hydroxy progesterone to androstenedione

17 α hydroxylase / 17, 20 lyase (CYP17 A1 )

21 hydroxylase (CYP21 A2)

11β- hydroxylase (CYP1 1B1)

3β-HSD2

Q 17. following enzyme converts 11 deoxycortisol to cortisol

17 α hydroxylase / 17, 20 lyase (CYP17 A1 )

21 hydroxylase (CYP21 A2)

11β- hydroxylase (CYP1 1B1)

3β-HSD2

Q 18. cortisol binding system in plasma is

transcortin

adrenocortin

epicortin

anacortin

Q 19. following is expressed in outer cell layer of adrenal cortex

17-hydroxylase

21-hydroxylase

aldosterone synthase

all of the above

Q 20. cortisol binding globulin level is increased in

pregnancy

oc pills administration

both of the above

none of the above

Q 21. number of carbon atoms in 17 hydroxycorticsteroids is

Q 22. albumin binding property for cortisol includes

high affinity, low capacity

low affinity, high capacity

high affinity , high capacity

low affinity , low capacity

Q 23. true statements about cortisol metabolites includes

biologically inactive

bind weakly to circulating plasma proteins

low levels in urine are typical of children with 3β-HSD2 deficiency

all of the above

Q 24. regarding adrenal steroidogenesis true statement includes

mineralocorticoid synthesis occurs in zona glomerulosa

glucocorticoids synthesis occurs in zona fasciculata

adrenal androgen synthesis occurs in zona reticularis

all of the above

Q 25. daily secretion of cortisol ranges between

5 and 10 mg

10 and 15 mg

15 and 30 mg

30 and 60 mg

Q 26. function of 11 β-HSD2 is

converting inactive cortisone to active cortisol

converting cortisol to inactive cortisone

promote binding of free cortisol to transcortin

inhibit binding of free cortisol to transcortin

Q 27. physiologically active form of cortisol is

free cortisol

protein bound cortisol

cortisol metabolites

all of the above

Q 28. steroid inactivation occurs in

liver

lung

kidney

all of the above

Q 29. cholesterol import into mitochondrion is initiated by the action of

phosphorylation of CREB

steroidogenic acute regulatory (StAR) protein

CYP11A1

all of the above

Q 30. cholesterol uptake by adrenal cortex is mediated by

LDL receptors

HDL receptors

VLDL receptors

all of the above

ENDOCRINOLOGY MCQs – Exercise 13

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ENDOCRINOLOGY MCQs – Exercise 13

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