GASTROINTESTINAL AND LIVER DISEASE – Exercise 1

Q 1. gut is the largest organ containing billions of organisms and still no significant inflammation present.this phenomenon is known as

Q 2. during a meal nutrients interact with cells in the mouth and GI tract to regulate hunger and satiety.which of the following does not play a major role in this complex interaction

Q 3. adrenergic neurons originate in ganglia of the ANS and synapse with enteric neurons.adrenergic neurons only contain which of the following

Q 4. CCK and somatostatin are both hormones that are released in the GI tract may work as which of the following

Q 5. which of the following characterstics is not associated with inherited GI cancer syndromes

Q 6. what is the phenomenon known as epithelial mesenchymal transition

Q 7. analog of which of the following is used to treat conditions of hormonrs excess produced by endocrine tumors

Q 8. Wnt pathwayis important in which of the following processes

Q 9. test performed on colon tumor tissue and can be helpful in identifying those individuals with colon cancer in the setting of hereditary nonpolyposis colorectal cancer

Q 10. which of the following represents an antigen that is most effective at inducing oral tolerance

Q 11. the highest frequency of mutations (90%) of Ras genes found in which of the following tumors

Q 12. Gardner syndrome gene is found on chromosome 5q.both somatic and germline mutations appear in this gene and contribute to the development of polyps

Q 13. the PP/PYY/NPY family of peptides functionas which type of transmitter

Q 14. which antibody is most abundant in mucosal secretions

Q 15. major function of glucagon and glucagon like peptide

Q 16. which of the following is the mediator of satiety and food intake

Q 17. which of the following pathway plays important role in GI tumors

Q 18. neuromodulator that ia apotent vasodilator and in GI tract stimulates fluid and electrolyte secretion from epithelium and bile duct cholingiocytes and also an important modulator of sphincter in the GI tract includes

Q 19. which of the following viruses have been linked to gastric lymphoepithelial malignancies

Q 20. modifications of the peptide hormone for the full biological activity occur in which organelle of the cell

Q 21. most populous cell of lamina propria mononuclear cells

Q 22. which of the following describes the major contributing mechanism behind the controlled inflammation in the gut

Q 23. genes deleted or mutated in pancreatic adenocarcinoma

Q 24. which of the following cytokines play a role in IgA secretion

Q 25. IECs are derived from the basal crypts and have many roles.which of the following is not a role of the IECs

Q 26. which of the following does not effect the induction of oral tolerance

Q 27. lamina propria mononuclear cells and lamina propria lymphocytes are involved in several pathways.which pathways may be defective in crohns disease

Q 28. poin mutations are rarely find in colonic adenomas,what is the gene

Q 29. all of the following are tumor suppressor genes except

Q 30. which of the following is overexpressed in patients with inflammatory bowel disease and may contribute to activate T lymphocytes