HEMATOLOGY MCQ – Exercise 19

The multiple choice questions in this online test paper focuses on HEMATOLOGY MCQ. If you are looking for self evaluation of your PG Medical entrance exam preparation then this online HEMATOLOGY MCQ Test Paper will help you to evaluate your exam preparation.

Instruction for REPRODUCTIVE BIOLOGY/ REPRODUCTIVE MEDICINE / INFERTILITY MCQs:

1- This online MCQ practice test paper contains 30 questions.
2- Each question in this online practice test paper have four options and only 1 option is correct.
3- You can view the answers of this practice test paper after submitting the practice test paper.
Note: The answers mentioned at the end of practice test are the best suitable option as per our knowledge. Users shall cross-check the answers with their textbooks.

Q 1. following illustrates the mutation in JAK2 in the pathogenesis of polycythemia vera

F617V

F716V

V617F

V716F

Q 2. true regarding polycythemia vera

clonal disorder

increased phenotypically normal RBC , WBC & platelets

absence of recognizable physiologic stimulus

all of the above

Q 3. Philadelphia negative myeloproliferative disorders

polycythemia Vera

essential thrombocytopenia

idiopathic myelofibrosis

all of the above

Q 4. characteristic feature of myeloproliferative disorders

marrow hypercellularity

thrombosis and hemorrhage

risk of leukemic transformation in long term

all of the above

Q 5. true regarding pathogenesis of polycythemia vera

erythropoietin independent erythroid colony formation

hypersensitivity of polycythemia vera erythroid progenitor cells to EPO

resistance of polycythemia vera progenitor cells to apoptosis

all of the above

Q 6. regarding myelophthisis true statement includes

myeloid metaplasia

pancytopenia

increased circulating hematopoietic progenitor cells

all of the above

Q 7. following typically distinguishes polycythemia vera from other causes of erythrocytosis

massive splenomegaly

high hemoglobin

high hematocrit

aquagenic pruritis

Q 8. false about JAK2

nuclear tyrosine kinase

intracellular signaling by receptors for erythropoietin

intracellular signaling by receptors for GM-CSF

intracellular signaling by receptors for thrombopoietin

Q 9. following conditions can transform into each other

polycythemia Vera

primary myelofibrosis

essential thrombocytosis

all of the above

Q 10. regarding polycythemia vera all are true except

erythroid progenitor cells are resistant to apoptosis

autonomous clonal form of erythrocytosis

levated plasma erythropoietin level excludes polycythemia vera as the cause for erythrocytosis

abundant bone marrow iron

Q 11. in secondary MDS latent period following cancer treatments is least with following which of the

DNA topoisomerase inhibitors

busulphan

nitrosurea

procarbazine

Q 12. in MDS prognosis strongly correlates with

hypogranulation in granulocytic precursors

ringed sideroblasts

proportion of marrow blasts

circulating myeloblasts

Q 13. thrombosis in polycythemia vera is due to

erythrocytosis

leucocytosis

thrombocytosis

all of the above

Q 14. following cause microcytic erythrocytosis

beta thallessemia trait

hypoxic erythrocytosis

polycythemia vera

all of the above

Q 15. spurious erythrocytosis is also called as

Budd-Chiari syndrome

Bartter’s syndrome

Gray platelet syndrome

Giesbock’s syndrme

Q 16. skin condition related to MDS

Gardner syndrome

Sweet’s syndrome

Cowden disease

Torre syndrome

Q 17. bone marrow in myelodysplasia may show all except

normal or hypercellularity

ringed sideroblasts

hypogranulation and hyposegmentation in granulocytic precursors

decrease in myeloblasts

Q 18. JAK2 gene is located on the

short arm of chromosome 9

long arm of chromosome 9

short arm of chromosome 10

long arm of chromosome 10

Q 19. Anagrelide is a

phosphodiesterase inhibitor

salicylate isomer

anticoagulant

cytotoxic agent

Q 20. most frequent class in WHO estimated proportion of patients with MDS

refractory anemia

refractory anemia with ringed sideroblasts

refractory cytopenias with multilineage dysplasia

refractory anemia with excess blasts Type 1

Q 21. false about MDS

idiopathic MDS is a disease of elderly

clonal hematopoietic stem cell disorder

apoptosis of marrow cells increased

none of the above

Q 22. normal range for plasma erythropoietin is

1 to 11 mU/mL

4 to 26 mU/mL

21 to 54 mU/mL

34 to 90 mU/mL

Q 23. intractable generalized pruritis in polycythemia vera responds to

hydroxyurea

interferon α

PUVA therapy

all of the above

Q 24. JAK2 V16F is present in what percentage of PMF patients

10%

25%

50%

75%

Q 25. following drugs has role in the treatment of MDS

azacytidine

amifostine

lenalidomide

all of the above

Q 26. following conditions can transform into each other

CML (chronic myeloid leukemia)

CNL (chronic neutrophilic leukemia)

CEL (chronic eosinophilic leukemia)

none of the above

Q 27. MDS includes

refractory anemia

refractory anemia with ringed sideroblasts

refractory anemia with excess blasts

all of the above

Q 28. regarding myelophthisis true statement includes

secondary myelofibrosis

leukoerytheroblastic blood smear

ineffective erytropoiesis

all are true

Q 29. chronic primary myelofibrosis characterized by all except

jaundice

marrow fibrosis

extramedullary hematopoiesis

splenomegaly

Q 30. following do not use the JAK-STAT pathway as their essential mode of signalling

erythropoietin

IL-1

thrombopoietin

growth hormone

HEMATOLOGY MCQ – Exercise 19

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HEMATOLOGY MCQ – Exercise 19

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