HEMATOLOGY MCQ – Exercise 21

The multiple choice questions in this online test paper focuses on HEMATOLOGY MCQ. If you are looking for self evaluation of your PG Medical entrance exam preparation then this online HEMATOLOGY MCQ Test Paper will help you to evaluate your exam preparation.

Instruction for REPRODUCTIVE BIOLOGY/ REPRODUCTIVE MEDICINE / INFERTILITY MCQs:

1- This online MCQ practice test paper contains 30 questions.
2- Each question in this online practice test paper have four options and only 1 option is correct.
3- You can view the answers of this practice test paper after submitting the practice test paper.
Note: The answers mentioned at the end of practice test are the best suitable option as per our knowledge. Users shall cross-check the answers with their textbooks.

Q 1. Sokal index staging system in CML includes all except

percentage of circulating blasts

spleen size

hemoglobin

platelet count

Q 2. following indicates poor prognosis in CML

splenomegaly

hepatomegaly

lymphadenopathy

bony tenderness

Q 3. Hasford staging system in CML does not include

cytogenetic clonal evolution

age

spleen size

percentage of circulating blasts

Q 4. true regarding CML

platelet counts are always elevated at diagnosis

leukocyte alkaline phosphatase is low

serum vitamin B12 and B-12 binding proteins are raised

all of the above

Q 5. BCR gene is present on chromosome

Q 6. in CML blast crisis is defined as blood or marrow blasts more than

10%

15%

20%

Q 7. Sokal index staging system in CML includes all except

cytogenetic clonal evolution

age

sex

percentage of circulating blasts

Q 8. progression of CML to blast crisis is accelerated by

alcohol ingestion

cigarette smoking

exercise

lack of sleep

Q 9. Philadelphia chromosome in classical CML patients present in approximately

75%

85%

95%

100%

Q 10. high dose of cytarabine toxicity includes

myelosupression

pulmonary fibrosis

irreversible cerebellar toxicity

all of the above

Q 11. Philadelphia chromosome can be addressed as

shortened chromosome 22 (22 q-)

shortened chromosome 9 (9 q-)

lengthened chromosome 22 (22 q+)

lengthened chromosome 9 (9 q+)

Q 12. in CML reciprocal translocation occurs between chromosoome

5 and 18

7 and 20

9 and 22

11 and 22

Q 13. untreated CML goes into blast crisis in a median time of

1 year

2 year

3 year

4 year

Q 14. in CML disease acceleration is defined by

increasing anemia

cytogenetic clonal evolution

blood or marrow blasts between 10 and 20% blood or marrow basophils ≥20% or platelet count <100,000 /µL

all of the above

Q 15. CML is characterized by

progressive granulocytosis

marrow hypercellularity

splenomegaly

all of the above

Q 16. Philadelphia chromosome is present in

all dividing cells of hematopoietic lineage

B cells

T cells

all of the above

Q 17. complete cytogenetic remission in CML treatment means

no bone marrow metaphases with t (9; 22)

<10% bone marrow metaphases with t (9; 22)

1-35% bone marrow metaphases with t (9; 22)

36-85% bone marrow metaphases with t (9; 22)

Q 18. BCR stands for

bridgepoint cluster region

breakpoint cluster region

bilateral cluster region

big cluster region

Q 19. patients who fail to attain complete remission after how many induction courses should proceed to allogenic stem cell transplant

Q 20. ABL-BCR fusion gene is present on chromosome

9q+

Q 21. ABL proto-oncogene is present on chromosome

Q 22. CML incidence increases slowly with age till mid forties then it starts

fall rapidly

rise rapidly

remains the same

any of the above

Q 23. following protects heart against anthracycline toxicity

ascorbic acid

iron

thiamine

dexrazoxane

Q 24. drug used in the treatment of acute promyelocytic leukemia

gemcitabine

etoposide

asparginase

tretinion

Q 25. in CML, translocation results in BCR gene fusion with ABL gene fusion in which manner

head to tail

tail to head

side to side

any of the above

Q 26. ABL-BCR fusion protein is found in

nucleus

cytoplasm

cell membrane

nuclear membrane

Q 27. complete hematologic remission in CML treatment means

wbc <10,000 / µL

normal blood morphology , hemoglobin and platelet counts

disappearance of splenomegaly

all of the above

Q 28. ABL named after

Abelson murine leukemia virus

Anderson murine leukemia virus

Atkin murine leukemia virus

Ashley murine leukemia virus

Q 29. following about CML is false

reciprocal translocation between chromosomes 9 and 22

BCR/ABL fusion protein is p210 BCR/ABL

chromosomal instability is a rule

there is direct evidence of a viral etiology

Q 30. most common physical finding in CML

splenomegaly

hepatomegaly

lymphadenopathy

bony tenderness

HEMATOLOGY MCQ – Exercise 21

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HEMATOLOGY MCQ – Exercise 21

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