NEUROLOGY MCQ – Exercise 33

The multiple choice questions in this online test paper focuses on NEUROLOGY MCQ. If you are looking for self evaluation of your PG Medical entrance exam preparation then this online NEUROLOGY MCQ Test Paper will help you to evaluate your exam preparation.

Instruction for REPRODUCTIVE BIOLOGY/ REPRODUCTIVE MEDICINE / INFERTILITY MCQs:

1- This online MCQ practice test paper contains 30 questions.
2- Each question in this online practice test paper have four options and only 1 option is correct.
3- You can view the answers of this practice test paper after submitting the practice test paper.
Note: The answers mentioned at the end of practice test are the best suitable option as per our knowledge. Users shall cross-check the answers with their textbooks.

Q 1. diseases due to genetic abnormalities of DNA mismatch /repair

Bloom`s syndrome

Ataxia telangiectasia

HNPCC

all of the above

Q 2. Bassen Kornzweig syndrome is an autosomal recessive disorder cause by defect in MTP gene resulting in

diabetes mellitus

cardiomyopathy

abetalipoproteinemia

hypothyroidism

Q 3. drugs of use in Friedreich`s ataxia

desferrioxamine

idebenone

ascorbic acid

all of the above

Q 4. sodium ion channelopathy includes all except

paramyotonia congenita

hyperkalemic periodic paralysis

hypokalemic periodic paralysis

generalized epilepsy with febrile convulsions plus

Q 5. true regarding ataxia with vitamin E deficiency

due to mutations in gene for α tocopherol transfer protein

autosomal recessive

chromosomal localization is on 8q13

all of the above

Q 6. calcium ion channelopathy includes all except

episodic ataxia-2

spinocerebellar ataxia-6

familial hemiplegic migraine

autosomal dominant progressive deafness

Q 7. neurologic genetic disorders inherited as X linked recessive traits include all except

Duchene muscular dystrophy

spinobulbar muscular atrophy

fragile X syndrome

friedreich’s ataxia

Q 8. which neurotransmitter functions by signaling in a retrograde fashion from postsynaptic to presynaptic cell

substance P

enkephalin

neuropeptide Y

nitric oxide and CO2

Q 9. large fiber sensory neuropathy includes

friedreich’s ataxia

lepromatous leprosy

diabetes mellitus

antiretroviral therapy neuropathy

Q 10. all are true regarding friedreich’s ataxia except

presents before 25 years of age

lower extremities more severely involved than upper

flexor plantar responses

absence of deep tendon reflexes

Q 11. which SCAs has presentation similar to Huntington disease

SCA1

SCA2

SCA3

SCA17

Q 12. primary site of pathology in Friedreich`s ataxia is

spinal cord

dorsal root ganglion cells

peripheral nerves

all of the above

Q 13. painful sensory an early feature of

hereditary sensory neuropathy , lepromatous leprosy

diabetic small fiber neuropathy , amyloidosis

Tangier disease , Fabry`s disease

all of the above

Q 14. a variant of AT(AT like disease) is caused by mutations of which gene

SBDS

MRE11

CHD 7

STAT5b

Q 15. neurologic genetic disorders inherited in Mendelian autosomal recessive mutations include all except

friedreich`s ataxia

Wilson`s disease

tuberous sclerosis

ataxia telangiectasia

Q 16. true regarding friedreich’s ataxia includes

frataxin is a mitochondrial protein for iron homeostasis

excess oxidized intramitochondrial iron

iron chelators and antioxidants are potentially harmful

all of the above

Q 17. classic form of friedreich’s ataxia an autosomal recessive disorder caused by mutation in gene FXN located on chromosome

Q 18. neurologic genetic disorders inherited in Mendelian autosomal dominant mutations include all except

Huntington`s disease, dystrophia myotonica, spinocerebellar ataxia

familial Alzheimer`s disease, Charcot Marie tooth disease 1A, tuberous sclerosis

ALS, HYPP, Charcot Marie tooth disease 1A

friedreich`s ataxia, ataxia telangiectasia, Wilsons disease

Q 19. other names for ataxia telangiectasia

A-T

ATM(ataxia telangiectasia mutated)

Louis –bar syndrome

all of the above

Q 20. pure sensory neuropathy cause includes

pyridoxine toxicity,vitamin B12 neuropathy

friedreich’s ataxia, idiopathic sensory neuropathy

sensory neuropathy associated with Sjogren syndrome,cisplatin neuropathy

all of the above

Q 21. ataxia telangiectasia is an autosomal recessive disorder caused by mutation in gene found on chromosome

Q 22. regarding neurotransmitter all are true except

ionotropic receptors are direct ion channels

metabotropic receptors interact with G proteins

ionotropic receptors are single subunits

kinetics of ionotropic receptor effects are fast

Q 23. pure motor neuropathy causes includes

GBS, CIDP , diabetic amyotrophy

MMN , AIP , brachial neuropathy

Diphtheria , lead , dapsone

all of the above

Q 24. episodic ataxia episodes are precipitated by

hunger

exercise

sleep

meals

Q 25. all are true regarding friedreich’s ataxia except

cardiac involvement occurs in 90% of patients

high incidence of diabetes mellitus

severe mental retardation

musculoskeletal deformities are common

Q 26. symptoms and episodic attacks of ataxia responsive responsive to

Lithium

atypical antipsychotic drugs

acetazolamide

electroconvulsive therapy

Q 27. AT causes

low IgA

IgG2 deficiency

low antibody production

all of the above

Q 28. potassium ion channelopathy includes all except

episodic ataxia1

episodic ataxia2

benign neonatal familial convulsions

Jervell and Lange- Nielsen syndrome

Q 29. typical MRI finding in friedreich’s ataxia is

brainstem atrophy

cerebellar SOL

thining of cervical Spinal cord

obstructive hydrocephalus

Q 30. classic form of friedreich’s ataxia an autosomal recessive disorder caused by mutation in gene FXN that encodes for

frataxin

ataxin 1

ataxin 2

all of the above

NEUROLOGY MCQ – Exercise 33

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NEUROLOGY MCQ – Exercise 33

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