Reproductive Biology / Medicine / Infertility MCQs – Exercise 23

The multiple choice questions in this online test paper focuses on Reproductive Biology / Reproductive Medicine / Infertility MCQ. If you are looking for self evaluation of your PG Medical entrance exam preparation then this online Reproductive Biology / Reproductive Medicine / Infertility MCQ Test Paper will help you to evaluate your exam preparation.

Instruction for REPRODUCTIVE BIOLOGY/ REPRODUCTIVE MEDICINE / INFERTILITY MCQs:

1- This online MCQ practice test paper contains 30 questions.
2- Each question in this online practice test paper have four options and only 1 option is correct.
3- You can view the answers of this practice test paper after submitting the practice test paper.
Note: The answers mentioned at the end of practice test are the best suitable option as per our knowledge. Users shall cross-check the answers with their textbooks.

Q 1. An andromedin is:

a cofactor that binds to androgens.

any virilizing hormone (any hormone that facilitates male sexual maturation).

a virilizing paracrine hormone that is secreted by a cell in response to androgen and does not require androgen receptor for its reception.

a receptor for a virilizing hormone.

Q 2. Concerning liver disease and BPH, which of the following statements is TRUE?

Ethanol consumption increases circulating levels of estrogens.

The risk of having surgery for BPH is increased in heavy drinkers.

The intake of ethanol can decrease serum testosterone levels by a variety of mechanisms.

Most autopsy studies find a higher prevalence of BPH in men with liver cirrhosis

Q 3. What is the source of fructose in seminal plasma?

Prostate gland

Bulbourethral gland

Vas deferens

Seminal vesicles

Q 4. With regard to the effects of estrogens in prostate development true statement include

Estrogens are not required for the development of a prostate .

ER-α regulates ductal formation.

ER-β is required for prostates to allow sperm to mature to an active form.

b and c

Q 5. Correct regarding the role of androgenic hormones in the etiology of BPH?

Testosterone and dihydrotestosterone are the sole causes of the hyperplasia taking place in the prostate after the age of 40 years.

The volume of androgen receptors in the prostate decreases with aging, leading to a lesser response to androgenic stimuli.

Dihydrotestosterone is considered the more potent of the androgenic steroid hormones by a factor of approximately 10 : 1.

Of the two 5α-reductase isoforms, type 1 is most commonly found in the prostate.

Q 6. Majority of testosterone in the plasma bound?

Insulin

TP53

Prostaglandins

Sex hormone–binding globulin (SHBG)

Q 7. TRUE regarding testosterone

Testosterone is synthesized by the Sertoli cells of the testes.

Testosterone is synthesized by the Leydig cells of the testes.

Testosterone is a direct precursor of pregnenolone.

5α-Reductase is an enzyme that converts DHT into testosterone.

Q 8. Which 5α-reductase isoform predominates in the prostate gland?

Type 1

Type 2

Type 3

Type 4

Q 9. DHEA has been suggested as a major source of testosterone within the plasma. What percentage of total testosterone has been determined to be derived from DHEA

15%

Q 10. Seminal plasma has unusually high concentrations of all of the following except:

zinc.

insulin.

fructose.

spermine

Q 11. Secretory products expressed by mature terminally differentiated prostate epithelial cells except

Prostate-specific antigen (PSA)

Prostate acid phosphatase

Androgen receptor

Synaptophysin

Q 12. Which α1-adrenergic receptor subtype is linked to smooth muscle contraction in the prostate?

αD

α1A

α1B

α2

Q 13. False include

TGF-β: Growth inhibitor

DHT: Activates transcription of androgen receptor target genes in the mesenchyme

Nkx3.1: Activates genes that drive septation of the cloaca

Noggin: Antagonizes binding of bone morphogenetic proteins at their receptors

Q 14. TRUE regarding prostate volume

International studies show significant similarity in prostate volume in white, age-stratified men.

Prostate volume assessment by digital rectal examination (DRE) is reproducible across examiners.

Although there is a steady increase in total prostate volume with age, the transition zone volume increases only marginally.

Magnetic resonance imaging measurements are, in general, smaller compared with transrectal ultrasound measurements.

Q 15. Normal concentration of DHT in the plasma of normal males is:

50 ng/dL.

100 ng/dL

200 ng/dL

300 ng/dL

Q 16. The prevalence of a disease is defined as the number of:

diseased people per 100,000 population per year.

existing cases per 100,000 population at a distinct target date.

deaths per 100,000 population per year.

deaths per number of diseased.

Q 17. TRUE statements regarding the International Prostate Symptom Score (IPSS) is?

Moderate symptom severity is defined as a score from 10 to 20 points.

The IPSS score addresses irritative and obstructive symptoms and issues of incontinence.

Quantitative symptom scores in BPH are not as important as are objective measures such as a flow rate recording.

The IPSS score has been translated and validated in many languages.

Q 18. Proportion of the total human ejaculate comes from the prostate

1/2

1/4

1/6

1/8

Q 19. TRUE regarding androgen receptor intracellular events

DHT or testosterone binding to specific nucleotide receptors in the cytoplasm

Dimerization and activation of the steroid receptor

Endocytosis of native androgen

Transport of the active receptor and androgen from the nucleus to the cell membrane

Q 20. Correct regarding genetic and familial factors in the etiology of BPH

There is no evidence that BPH is a familial disease.

Any man who underwent TURP should alert his sons that their chance of having to have TURP is three times greater than age-matched controls.

Cases of familial BPH tend to occur in men with smaller prostates than the sporadic cases of BPH.

Approximately 50% of cases of BPH in men who undergo surgery when younger than the age of 60 are estimated to be inheritable.

Q 21. All are characteristic of a prostate intermediate epithelial cell except

keratin 5/14.

keratin 8/18.

c-kit.

proliferative activity.

Q 22. Of the following biomarkers not a characteristic of prostate stem cells

Sca1

Keratins 5/14

Enrichment in proximal prostatic ducts

PSA

Q 23. For chromatin remodeling and activation of transcription all which molecular components is required except

CPB/p300

SWI-SNF

Histone 1A (H1A)

Androgen receptor

Q 24. TRUE regarding neuroendocrine cells found within the prostate?

The major secretory product is serotonin.

A minor component of the secretory products is bombesin.

Another name for them is AFUD.

A major secretory product of the neuroendocrine cells is TSH.

Q 25. Half life of testosterone

10-20 seconds

10-20 minutes

10-20 hours

10-20 days

Q 26. All are well-recognized type of growth control regulating the prostate?

Endocrine factors

Neuroendocrine factors

Anabolic factors

Autocrine factors

Q 27. How many isoforms of 5α-reductase exist?

Q 28. Autopsy prevalence of BPH or stromoglandular hyperplasia:

no adequate studies have been done to date.

it is commonly found in men of all ages.

it is very uncommon in men younger than the age of 30 years.

it is found in 100% of men beginning at the age of 40 years.

Q 29. Secretory products of the prostate include all except

hK17.

prostate-specific transglutaminase 4.

KLK-L11.

prostatic acid phosphatase (PAP).

Q 30. Following biologic functions is not regulated by the laminins

Cell adhesion

Proliferation

Differentiation

Chromatin remodeling

Reproductive Biology / Medicine / Infertility MCQs – Exercise 23

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Reproductive Biology / Medicine / Infertility MCQs – Exercise 23

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